Cart
sales@molnova.com
Lobeline hydrochloride
CAS No. 134-63-4
Lobeline hydrochloride( Lobeline hydrochloride )
Catalog No. M11393 CAS No. 134-63-4
Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 41 | In Stock |
|
| 100MG | 74 | In Stock |
|
| 200MG | 87 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLobeline hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionLobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.
-
DescriptionLobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.
-
In Vitro——
-
In VivoAnimal Model:Sprague-Dawley rats (200-250 g) Dosage:0.3 mg/kg, 1.0 mg/kg, and 3.0 mg/kg for acute administration; 3 mg/kg for chronic administration Administration:Subcutaneous injection; 15 min prior to measurement, or every 15 min for 7 sessions; separated by 2 intervening maintenance days of d-methamphetamine (0.05 mg/kg/infusion) self-administration Result:Decreased d-methamphetamine Self-Administration.
-
SynonymsLobeline hydrochloride
-
PathwayEndocrinology/Hormones
-
TargetAChR
-
RecptornAChR| Nicotinic Receptor
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number134-63-4
-
Formula Weight273.92
-
Molecular FormulaC22H27NO2·HCl
-
Purity>98% (HPLC)
-
SolubilityWater: 1g/40mL
-
SMILESCN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3.[H]Cl
-
Chemical Name2-[(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone hydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Meyer AC, et al. J Neurochem. 2013 Oct;127(2):187-98.
molnova catalog
related products
-
Carbaryl
A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors.
-
PNU 282987
PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
-
α-Bungarotoxin
Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM and > 3 μM respectively).
